Herbal Pharmacokinetics: A Practitioner Update With Reference to St. John’s Wort (Hypericum perforatum) Herb-Drug Interactions
نویسنده
چکیده
Why Pharmacokinetics? Herbalists have long studied the effect of herbal medicines on the body, but have hitherto paid less attention to the effects of the body on herbal medicines. This dichotomy expresses the distinction in classical pharmacology between pharmacodynamics and pharmacokinetics. For a given dose of any herbal medicine, its physiological effect (or that of its constituents) will be governed by the effective tissue concentration of the remedy which in turn is determined by pharmacokinetic parameters – the absorption, distribution, metabolism and excretion of its various components. Knowledge of herbal pharmacokinetics can provide valuable information to aid practitioners in prescribing herbs safely and effectively. It may also enable useful predictions to be made, for example regarding possible interactions between herbal remedies and conventional pharmaceuticals.
منابع مشابه
Pharmacokinetic interactions of Hypericum perforatum L. (St John's wort) with conventional drugs: a review of clinical studies
Background and objectives: Hypericum perforatum L., commonly known as St. John’s wort (SJW) from the family Hypericaceae is a famous medicinal plant used to treat mild to moderate depression; so, it might affect the pharmacokinetics of numerous drugs. Due to widespread herb-drug interactions of SJW, this study was designed to review the clinical evidences regarding the...
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